Manchester United will be without Nani, Johnny Evans and Phil Jones for tonight's round of 16 first leg against Olympiakos in Greece.
Juan Mata is not available as he is cup tied.
The Greeks are 20 points clear at the top of their league and are unbeaten domestically this season although United have won all four of the clubs' past encounters.
In the evenings other match Zenit Saint Petersburg host Borussia Dortmund , that game starts at 5.
Meanwhile, it's being reported that Ireland will face England in a friendly in Dublin in May 2015.
The sides met at Wembley this summer, and a return date was never confirmed in case the two were drawn against each other in Euro Qualifying.
Since that hasn't happened they are free to meet in a game the FAI hope will take place next year.
