Tottenham can become the new Premier League leaders, for a couple of hours at least, with victory of Arsenal in the early kick-off.
They meet in a battle of second and third in the North London Derby at White Hart Lane at 12:45.
Arsenal will be deserate for a win after their mid-week home defeat to Swansea.
Manager Arsene Wenger doesn't think the match will be decisive – as there are bound to be more surprises in the remainder of the season.
Another of the title contenders, Man City, are in action at three as they host bottom-side Aston Villa.
Two massive games in the battle against relegation as second-from-bottom Newcastle United play 15th placed Bournemouth and third-from-bottom Norwich play 16th place Swansea.
Sunderland are just outside the drop zone as they go to Southampton, also at three, Chelsea host Stoke City .
The late game sees current leaders Leicester City, who were bottom of the table at this time last season, make the trip to Watford. Kick-off is at 5:30pm.