Killaloe’s Damien Varley will captain Munster in Friday’s match away to Zebre.
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Varley starts at hooker, and joins Dave Kilcoyne and John Ryan in the front row in a much-changed Munster team.
Ex Leinster winger Andrew Conway will make his debut, while JJ Hanarahan and Cathal Sheridan are the half-backs.
Donnacha Ryan also makes his first start of the season and partners Ian Nagle in the second row.
