Arsenal will have a mountain to climb on the French Riviera on St. Patrick's Day.
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The Gunners lost 3-1 at home to Monaco in the first leg of their Champions League last-16 tie.
Alex Oxlade-Chamberlain's late goal to make it 2-1 had looked to have given hope to Arsene Wenger's side, but Yannick Ferreira-Carrasco restored Monaco's two-goal advantage.
It was also a bad night for last year's beaten finalists, with Atletico Madrid going down 1-nil away to Bayer Leverkusen