Liverpool look to overturn a 2-0 deficit against Zenit Saint Petersburg at Anfield while Frank Lampard will be rested for Chelsea who host Sparta Prague holding a 1-0 lead.
Both the matches at Stamford Brige and Anfield kick off at five past eight.
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At 6 Newcastle face Metalist Kharkiv in Ukraine with the tie scoreless while Spurs are Lyon , Tottenham lead 2-1 going into that match but are without Jermain Defoe meaning Emmaneul Adebayour will start up front.
The Magpies Hatem Ben Arfa hasn’t travelled having failed to recover from a hamstring injury.
Manager Alan Pardew admits the tie against the Ukrainian outfit is finely poised.