Jose Mourinho will be aiming to lead United to the fifth round of the FA Cup just days after his side booked a place in the EFL Cup final.
Jose Mourinho will be aiming to lead United to the fifth round of the FA Cup just days after his side booked a place in the EFL Cup final.
They face Championship side Wigan, who are managed by former United under-21 coach Warren Joyce.
That kicks-off at Old Trafford at 4pm.
Elsewhere, Watford kick start the day's action against League One Millwall at 12 while fellow Premier League side Hull City face Championship side Fullham at 12:30.
Conference side Sutton United will be hoping to cause an upset at Championship side Leeds at 2pm.
Non-league Lincoln pulled off one of the shocks of the day in the fourth round yesterday.
They came from behind to beat Championship leaders Brighton 3-1.
Liverpool suffered a 2-1 defeat at home to Championship side Wolves.
Third tier Oxford were 3-nil winners over Newcastle.
League Two Wycombe were denied a replay with Premier League Tottenham after conceding an injury time goal to lose 4-3 at White Hart Lane.
Elsewhere, Arsenal thrashed Southampton 5-nil while top flight leaders Chelsea eased past Brentford 4-nil
Manchester City secured a 3-0 victory at fellow top-flight side Crystal Palace.
Middlesbrough are through to the fifth round following their 1-0 win over Accrington Stanley and Burnley beat Bristol City 2-0.