Manchester United aim to extend their winning run in the Premier League to six games later.
They go to leaders Chelsea and are currently 8 points behind their opponents, having played a game more.
Kick-off at Stamford Bridge is at half-past-5.
With Liverpool on FA Cup semi final duty tomorrow, Southampton can reclaim fifth spot with a win at Stoke.
At the other end of the table, Burnley can climb out of the bottom three with a win at Everton.
Leicester can also improve their prospects of safety with Swansea visiting the King Power.
West Brom need to arrest a run of three defeats on the bounce to help secure their safety, when they go to in-form Crystal Palace.
Wembley hosts the first of the weekend's FA Cup semi finals this evening, with holders Arsenal facing Championship side Reading from 5.20.
