Up to 20 people who underwent surgery at Beaumont Hospital in Dublin could be at risk of contracting CJD.
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An investigation is underway at the hospital after a patient who was operated on was diagnosed with the fatal de-generative brain condition two weeks later.
The disease can be passed on through contaminated surgical instruments.
The HSE is to make contact with all those placed at risk and a helpline has opened on 1800 302 602.
Head of Health Protection at the HSE Kevin Kelleher says they were informed of the diagnosis at the end of last week: